For a long time, researchers have been trying different ways to reverse a mechanism of aging, which may not be sufficiently countered by the healthy lifestyle choices a better part of society currently follows.

Normal Aging Effects

In normal aging, it is typical to notice increase in fatigue and low motivation. The tiredness you feel on the outside is a true representation of the inward impairment of cellular activities that are critical to supporting and sustaining life.

NAD+ and Cellular Functions

Nicotinamide adenine dinucleotide (NAD+) is a very important cellular compound in scientific research. This compound is found in every living cell of both plants and animals, including bacteria. This means it is inherently essential to life. The two most essential functions of NAD+ to supporting life are:

i) It enables the transfer and conversion of energy from dietary foods to important functions of the cell.
ii) It is also hugely important in fighting genes that quicken degenerative aging processes

When NAD+ declines, functions of the mitochondria are impaired. This results in the degeneration of most cells leaving only a few mitochondria surviving. It eventually becomes a vicious cycle of the depletion of mitochondria, causing most of the physical signs of aging.

The challenge, therefore, facing society today is finding effective means to affordably enhance NAD+ cellular levels, especially among aging humans.

NAD+ Role In Controlled Aging

Researchers have been investigating NAD+ with regard to offering therapeutic interventions to age related degenerative disease. Numerous studies have given compelling findings showing that NAD+ has a special ability to:

• Protect tissues
• Induce DNA repair
• Increase life span
• Protecting Tissues (Against Mitochondrial Dysfunction)

For many years, nicotinamide adenine dinucleotide has been known to play a leading role in the transfer of energy that glucose and fatty acids release, to the mitochondria where it is metabolized into cellular energy. Metabolism is the breakdown of chemical energy (such as from glucose and fatty acids) into cellular energy.

NAD+ and its metabolites help in the transfer of energy in the form of electrons. The electron discharge and charge is what gives cellular energy. This is why our bodies are able to generate heat and keep warm. It also explains why sometimes NAD+ is referred to as an electron carrier molecule.

With insufficient NAD+, energy transfer halts in the cells, leading to age-related mitochondrial dysfunction.

Longevity

NAD+ is an indispensible cofactor of important enzymes responsible for sustaining life known as sirtuins. While there are other compounds like resveratrol, which are well known to activate sirtuin, evidence suggests that the activation is done indirectly. NAD+ is uniquely functioned since it activates sirtuins directly to regulate the genes responsible for aging.

There are seven different types of sirtuins enzymes, each working differently to support life. SIRT1 and SIRT3, are closely linked to longer life by their control of how genes degenerate. Just like other sirtuins, SIRT1&3 also depend on NAD+ to function. More research demonstrates how sirtuins neutralize particular genes responsible for aging, like those that cause inflammation, those involved in the synthesis and storage of fat, and in the management of blood sugar (insulin).